Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
Identifieur interne : 000798 ( Main/Exploration ); précédent : 000797; suivant : 000799Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
Auteurs : Mattia Volta [Canada] ; Stefano Cataldi [Canada] ; Dayne Beccano-Kelly [Canada] ; Lise Munsie [Canada] ; Igor Tatarnikov [Canada] ; Patrick Chou [Canada] ; Sabrina Bergeron [Canada] ; Emma Mitchell [Canada] ; Roscoe Lim [Canada] ; Jaskaran Khinda [Canada] ; Alejandro Lloret [États-Unis] ; C Frank Bennett [États-Unis] ; Carmela Paradiso [Italie] ; Michele Morari [Italie] ; Matthew J. Farrer [Canada] ; Austen J. Milnerwood [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Blotting, Western, Chromosomes, Artificial, Bacterial, Cognition Disorders (genetics), Corpus Striatum (metabolism), Disease Models, Animal, Dopamine (secretion), Humans, Immunohistochemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity (physiology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Protein-Serine-Threonine Kinases (genetics).
- MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical , secretion : Dopamine.
- genetics : Cognition Disorders, Parkinson Disease.
- metabolism : Corpus Striatum, Parkinson Disease.
- physiology : Motor Activity.
- Animals, Blotting, Western, Chromosomes, Artificial, Bacterial, Disease Models, Animal, Humans, Immunohistochemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic.
Abstract
Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. Comparative cognitive and motor behavioral testing of LRRK2 KO, overexpressor and mutant overexpressor mice has not previously been reported.
DOI: 10.1016/j.parkreldis.2015.07.025
PubMed: 26282470
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000411
- to stream PubMed, to step Curation: 000411
- to stream PubMed, to step Checkpoint: 000411
- to stream Ncbi, to step Merge: 001C81
- to stream Ncbi, to step Curation: 001C81
- to stream Ncbi, to step Checkpoint: 001C81
- to stream Main, to step Merge: 000799
- to stream Main, to step Curation: 000798
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.</title><author><name sortKey="Volta, Mattia" sort="Volta, Mattia" uniqKey="Volta M" first="Mattia" last="Volta">Mattia Volta</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Cataldi, Stefano" sort="Cataldi, Stefano" uniqKey="Cataldi S" first="Stefano" last="Cataldi">Stefano Cataldi</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Beccano Kelly, Dayne" sort="Beccano Kelly, Dayne" uniqKey="Beccano Kelly D" first="Dayne" last="Beccano-Kelly">Dayne Beccano-Kelly</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Munsie, Lise" sort="Munsie, Lise" uniqKey="Munsie L" first="Lise" last="Munsie">Lise Munsie</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Tatarnikov, Igor" sort="Tatarnikov, Igor" uniqKey="Tatarnikov I" first="Igor" last="Tatarnikov">Igor Tatarnikov</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Chou, Patrick" sort="Chou, Patrick" uniqKey="Chou P" first="Patrick" last="Chou">Patrick Chou</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Bergeron, Sabrina" sort="Bergeron, Sabrina" uniqKey="Bergeron S" first="Sabrina" last="Bergeron">Sabrina Bergeron</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Emma" sort="Mitchell, Emma" uniqKey="Mitchell E" first="Emma" last="Mitchell">Emma Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Roscoe" sort="Lim, Roscoe" uniqKey="Lim R" first="Roscoe" last="Lim">Roscoe Lim</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Khinda, Jaskaran" sort="Khinda, Jaskaran" uniqKey="Khinda J" first="Jaskaran" last="Khinda">Jaskaran Khinda</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Lloret, Alejandro" sort="Lloret, Alejandro" uniqKey="Lloret A" first="Alejandro" last="Lloret">Alejandro Lloret</name><affiliation wicri:level="2"><nlm:affiliation>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bennett, C Frank" sort="Bennett, C Frank" uniqKey="Bennett C" first="C Frank" last="Bennett">C Frank Bennett</name><affiliation wicri:level="2"><nlm:affiliation>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Paradiso, Carmela" sort="Paradiso, Carmela" uniqKey="Paradiso C" first="Carmela" last="Paradiso">Carmela Paradiso</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara</wicri:regionArea><wicri:noRegion>44121 Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Morari, Michele" sort="Morari, Michele" uniqKey="Morari M" first="Michele" last="Morari">Michele Morari</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara</wicri:regionArea><wicri:noRegion>44121 Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada. Electronic address: mfarrer@can.ubc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Milnerwood, Austen J" sort="Milnerwood, Austen J" uniqKey="Milnerwood A" first="Austen J" last="Milnerwood">Austen J. Milnerwood</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada; Division of Neurology, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: amilnerwood@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics, Canada; Division of Neurology, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26282470</idno><idno type="pmid">26282470</idno><idno type="doi">10.1016/j.parkreldis.2015.07.025</idno><idno type="wicri:Area/PubMed/Corpus">000411</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000411</idno><idno type="wicri:Area/PubMed/Curation">000411</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000411</idno><idno type="wicri:Area/PubMed/Checkpoint">000411</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000411</idno><idno type="wicri:Area/Ncbi/Merge">001C81</idno><idno type="wicri:Area/Ncbi/Curation">001C81</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C81</idno><idno type="wicri:Area/Main/Merge">000799</idno><idno type="wicri:Area/Main/Curation">000798</idno><idno type="wicri:Area/Main/Exploration">000798</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.</title><author><name sortKey="Volta, Mattia" sort="Volta, Mattia" uniqKey="Volta M" first="Mattia" last="Volta">Mattia Volta</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Cataldi, Stefano" sort="Cataldi, Stefano" uniqKey="Cataldi S" first="Stefano" last="Cataldi">Stefano Cataldi</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Beccano Kelly, Dayne" sort="Beccano Kelly, Dayne" uniqKey="Beccano Kelly D" first="Dayne" last="Beccano-Kelly">Dayne Beccano-Kelly</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Munsie, Lise" sort="Munsie, Lise" uniqKey="Munsie L" first="Lise" last="Munsie">Lise Munsie</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Tatarnikov, Igor" sort="Tatarnikov, Igor" uniqKey="Tatarnikov I" first="Igor" last="Tatarnikov">Igor Tatarnikov</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Chou, Patrick" sort="Chou, Patrick" uniqKey="Chou P" first="Patrick" last="Chou">Patrick Chou</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Bergeron, Sabrina" sort="Bergeron, Sabrina" uniqKey="Bergeron S" first="Sabrina" last="Bergeron">Sabrina Bergeron</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Mitchell, Emma" sort="Mitchell, Emma" uniqKey="Mitchell E" first="Emma" last="Mitchell">Emma Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Lim, Roscoe" sort="Lim, Roscoe" uniqKey="Lim R" first="Roscoe" last="Lim">Roscoe Lim</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Khinda, Jaskaran" sort="Khinda, Jaskaran" uniqKey="Khinda J" first="Jaskaran" last="Khinda">Jaskaran Khinda</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Lloret, Alejandro" sort="Lloret, Alejandro" uniqKey="Lloret A" first="Alejandro" last="Lloret">Alejandro Lloret</name><affiliation wicri:level="2"><nlm:affiliation>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bennett, C Frank" sort="Bennett, C Frank" uniqKey="Bennett C" first="C Frank" last="Bennett">C Frank Bennett</name><affiliation wicri:level="2"><nlm:affiliation>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Isis Pharmaceuticals Inc, 2855 Gazelle Court, Carlsbad, CA 92010</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Paradiso, Carmela" sort="Paradiso, Carmela" uniqKey="Paradiso C" first="Carmela" last="Paradiso">Carmela Paradiso</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara</wicri:regionArea><wicri:noRegion>44121 Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Morari, Michele" sort="Morari, Michele" uniqKey="Morari M" first="Michele" last="Morari">Michele Morari</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dept. of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara</wicri:regionArea><wicri:noRegion>44121 Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada. Electronic address: mfarrer@can.ubc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics</wicri:regionArea></affiliation></author><author><name sortKey="Milnerwood, Austen J" sort="Milnerwood, Austen J" uniqKey="Milnerwood A" first="Austen J" last="Milnerwood">Austen J. Milnerwood</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Applied Neurogenetics, Canada; Division of Neurology, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address: amilnerwood@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Applied Neurogenetics, Canada; Division of Neurology, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Chromosomes, Artificial, Bacterial</term><term>Cognition Disorders (genetics)</term><term>Corpus Striatum (metabolism)</term><term>Disease Models, Animal</term><term>Dopamine (secretion)</term><term>Humans</term><term>Immunohistochemistry</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Motor Activity (physiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Protein-Serine-Threonine Kinases (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Chromosomes, Artificial, Bacterial</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunohistochemistry</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. Comparative cognitive and motor behavioral testing of LRRK2 KO, overexpressor and mutant overexpressor mice has not previously been reported.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Volta, Mattia" sort="Volta, Mattia" uniqKey="Volta M" first="Mattia" last="Volta">Mattia Volta</name></noRegion><name sortKey="Beccano Kelly, Dayne" sort="Beccano Kelly, Dayne" uniqKey="Beccano Kelly D" first="Dayne" last="Beccano-Kelly">Dayne Beccano-Kelly</name><name sortKey="Bergeron, Sabrina" sort="Bergeron, Sabrina" uniqKey="Bergeron S" first="Sabrina" last="Bergeron">Sabrina Bergeron</name><name sortKey="Cataldi, Stefano" sort="Cataldi, Stefano" uniqKey="Cataldi S" first="Stefano" last="Cataldi">Stefano Cataldi</name><name sortKey="Chou, Patrick" sort="Chou, Patrick" uniqKey="Chou P" first="Patrick" last="Chou">Patrick Chou</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><name sortKey="Khinda, Jaskaran" sort="Khinda, Jaskaran" uniqKey="Khinda J" first="Jaskaran" last="Khinda">Jaskaran Khinda</name><name sortKey="Lim, Roscoe" sort="Lim, Roscoe" uniqKey="Lim R" first="Roscoe" last="Lim">Roscoe Lim</name><name sortKey="Milnerwood, Austen J" sort="Milnerwood, Austen J" uniqKey="Milnerwood A" first="Austen J" last="Milnerwood">Austen J. Milnerwood</name><name sortKey="Mitchell, Emma" sort="Mitchell, Emma" uniqKey="Mitchell E" first="Emma" last="Mitchell">Emma Mitchell</name><name sortKey="Munsie, Lise" sort="Munsie, Lise" uniqKey="Munsie L" first="Lise" last="Munsie">Lise Munsie</name><name sortKey="Tatarnikov, Igor" sort="Tatarnikov, Igor" uniqKey="Tatarnikov I" first="Igor" last="Tatarnikov">Igor Tatarnikov</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Lloret, Alejandro" sort="Lloret, Alejandro" uniqKey="Lloret A" first="Alejandro" last="Lloret">Alejandro Lloret</name></region><name sortKey="Bennett, C Frank" sort="Bennett, C Frank" uniqKey="Bennett C" first="C Frank" last="Bennett">C Frank Bennett</name></country><country name="Italie"><noRegion><name sortKey="Paradiso, Carmela" sort="Paradiso, Carmela" uniqKey="Paradiso C" first="Carmela" last="Paradiso">Carmela Paradiso</name></noRegion><name sortKey="Morari, Michele" sort="Morari, Michele" uniqKey="Morari M" first="Michele" last="Morari">Michele Morari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000798 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000798 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26282470
|texte= Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26282470" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |